Retinoid Signaling Determines Germ Cell Fate in Mice-Reference-Cited by-同舟云学术

Retinoid Signaling Determines Germ Cell Fate in Mice

Published:2006-04-28 Issue:5773 Volume:312 Page:596-600
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bowles Josephine¹²³⁴⁵,Knight Deon¹²³⁴⁵,Smith Christopher¹²³⁴⁵,Wilhelm Dagmar¹²³⁴⁵,Richman Joy¹²³⁴⁵,Mamiya Satoru¹²³⁴⁵,Yashiro Kenta¹²³⁴⁵,Chawengsaksophak Kallayanee¹²³⁴⁵,Wilson Megan J.¹²³⁴⁵,Rossant Janet¹²³⁴⁵,Hamada Hiroshi¹²³⁴⁵,Koopman Peter¹²³⁴⁵

Affiliation:

1. Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.

2. Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.

3. Department of Oral Health Science, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

4. Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Osaka 565-0871, Japan.

5. Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

Abstract

Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and inititate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes of Cyp26b1 -knockout mouse embryos, germ cells enter meiosis precociously, as if in a normal ovary. Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. Primordial germ cells in the mouse

2. Entry of Mouse Embryonic Germ Cells into Meiosis

3. A subtractive gene expression screen suggests a role forvanin-1 in testis development in mice

4. Proliferation and migration of primordial germ cells in We/We mouse embryos

5. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism

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