Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5-Reference-Cited by-同舟云学术

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

Published:1997-07-11 Issue:5323 Volume:277 Page:225-228
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Giannelli Gianluigi¹²³⁴,Falk-Marzillier Jutta¹²³⁴,Schiraldi Oronzo¹²³⁴,Stetler-Stevenson William G.¹²³⁴,Quaranta Vito¹²³⁴

Affiliation:

1. G. Giannelli, Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA, and Institute of Clinica Medica II, Università degli Studi Bari, 70124 Bari, Italy.

2. J. Falk-Marzillier and V. Quaranta, Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

3. O. Schiraldi, Institute of Clinica Medica II, Università degli Studi Bari, 70124 Bari, Italy.

4. W. G. Stetler-Stevenson, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Structural changes in the extracellular matrix are necessary for cell migration during tissue remodeling and tumor invasion. Specific cleavage of laminin-5 (Ln-5) by matrix metalloprotease–2 (MMP2) was shown to induce migration of breast epithelial cells. MMP2 cleaved the Ln-5 γ2 subunit at residue 587, exposing a putative cryptic promigratory site on Ln-5 that triggers cell motility. This altered form of Ln-5 is found in tumors and in tissues undergoing remodeling, but not in quiescent tissues. Cleavage of Ln-5 by MMP2 and the resulting activation of the Ln-5 cryptic site may provide new targets for modulation of tumor cell invasion and tissue remodeling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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