Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer

Author:

Adams Ralph W.12,Aguilar Juan A.12,Atkinson Kevin D.12,Cowley Michael J.12,Elliott Paul I. P.12,Duckett Simon B.12,Green Gary G. R.12,Khazal Iman G.12,López-Serrano Joaquín12,Williamson David C.12

Affiliation:

1. Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.

2. York Neuroimaging Centre, The Biocentre York Science Park, University of York, Heslington, York, YO10 5DG, UK.

Abstract

The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the small population difference between spin states even in high magnetic fields. Hyperpolarization methods can be used to increase this difference and thereby enhance signal strength. This has been achieved previously by incorporating the molecular spin singlet para-hydrogen into hydrogenation reaction products. We show here that a metal complex can facilitate the reversible interaction of para-hydrogen with a suitable organic substrate such that up to an 800-fold increase in proton, carbon, and nitrogen signal strengths are seen for the substrate without its hydrogenation. These polarized signals can be selectively detected when combined with methods that suppress background signals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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3. Nuclear Magnetic Resonance Imaging in Medicine and Biology 1986

4. C. R. Bowers, D. P. Weitekamp, J. Am. Chem. Soc.109, 5541 (1987).

5. Materials and methods are available as supporting material on Science Online.

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