An environment-dependent transcriptional network specifies human microglia identity-Reference-Cited by-同舟云学术

An environment-dependent transcriptional network specifies human microglia identity

Published:2017-06-23 Issue:6344 Volume:356 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gosselin David¹^ORCID,Skola Dylan¹^ORCID,Coufal Nicole G.²³^ORCID,Holtman Inge R.¹⁴,Schlachetzki Johannes C. M.¹^ORCID,Sajti Eniko³,Jaeger Baptiste N.²^ORCID,O’Connor Carolyn²^ORCID,Fitzpatrick Conor²,Pasillas Martina P.¹^ORCID,Pena Monique²,Adair Amy²^ORCID,Gonda David D.⁵^ORCID,Levy Michael L.⁵^ORCID,Ransohoff Richard M.⁶^ORCID,Gage Fred H.²^ORCID,Glass Christopher K.¹⁷^ORCID

Affiliation:

1. Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.

2. Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1002, USA.

3. Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.

4. Department of Neuroscience, section Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

5. Department of Neurosurgery, University of California, San Diego–Rady Children’s Hospital, San Diego, CA 92123, USA.

6. Neuroimmunology, Biogen, 225 Binney Street, Cambridge, MA 02142, USA.

7. Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.

Abstract

Of mice and men's microglia Microglia are immune system cells that function in protecting and maintaining the brain. Gosselin et al. examined the epigenetics and RNA transcripts from single microglial cells and observed consistent profiles among samples despite differences in age, sex, and diagnosis. Mouse and human microglia demonstrated similar microglia-specific gene expression profiles, as well as a shared environmental response among microglia collected either immediately after surgery (ex vivo) or after culturing (in vitro). Interestingly, those genes exhibiting differences in expression between humans and mice or after culturing were often implicated in neurodegenerative diseases. Science , this issue p. eaal3222

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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