Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response

Author:

Schwechheimer Claus1,Serino Giovanna1,Callis Judy2,Crosby William L.3,Lyapina Svetlana4,Deshaies Raymond J.4,Gray William M.5,Estelle Mark5,Deng Xing-Wang1

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520–8104, USA.

2. Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.

3. Plant Biotechnology Institute, National Research Council, Saskatoon SK S7N OW9, Canada.

4. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

5. Institute for Molecular and Cellular Biology, Section of Molecular, Cellular, and Developmental Biology, University of Texas, Austin, TX 78712, USA.

Abstract

The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis . Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCF TIR1 . Furthermore, we found that the COP9 signalosome and SCF TIR1 interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCF TIR1 . Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase–mediated responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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