Protein condensates as aging Maxwell fluids-Reference-Cited by-同舟云学术

Protein condensates as aging Maxwell fluids

Published:2020-12-11 Issue:6522 Volume:370 Page:1317-1323
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jawerth Louise¹²^ORCID,Fischer-Friedrich Elisabeth³⁴^ORCID,Saha Suropriya¹,Wang Jie²^ORCID,Franzmann Titus²⁴^ORCID,Zhang Xiaojie⁵^ORCID,Sachweh Jenny⁵^ORCID,Ruer Martine²^ORCID,Ijavi Mahdiye²^ORCID,Saha Shambaditya⁶^ORCID,Mahamid Julia⁵^ORCID,Hyman Anthony A.²³⁷^ORCID,Jülicher Frank¹³⁷^ORCID

Affiliation:

1. Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany.

2. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.

3. Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany.

4. Biotec, TU Dresden, Tatzberg 47-49, 01307 Dresden, Germany.

5. EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany.

6. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohrgasse 3, 1030 Vienna, Austria.

7. Center for Systems Biology Dresden, Pfotenhauerstr. 108, 01307 Dresden, Germany.

Abstract

Rheology of aging protein condensates Protein condensates that form by undergoing liquid-liquid phase separation will show changes in their rheological properties with time, a process known as aging. Jawerth et al. used laser tweezer–based active and microbead-based passive rheology to characterize the time-dependent material properties of protein condensates (see the Perspective by Zhang). They found that condensate aging is not gelation of the condensates, but rather a changing viscoelastic Maxwell liquid with a viscosity that strongly increases with age, whereas the elastic modulus stays the same. Science , this issue p. 1317 ; see also p. 1271

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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