Transgenic Metarhizium rapidly kills mosquitoes in a malaria-endemic region of Burkina Faso-Reference-Cited by-同舟云学术

Transgenic Metarhizium rapidly kills mosquitoes in a malaria-endemic region of Burkina Faso

Published:2019-05-31 Issue:6443 Volume:364 Page:894-897
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lovett Brian¹^ORCID,Bilgo Etienne²^ORCID,Millogo Souro Abel²,Ouattarra Abel Kader²^ORCID,Sare Issiaka²^ORCID,Gnambani Edounou Jacques²^ORCID,Dabire Roch K.²^ORCID,Diabate Abdoulaye²^ORCID,St. Leger Raymond J.¹^ORCID

Affiliation:

1. Department of Entomology, University of Maryland, College Park, MD 20742, USA.

2. Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Burkina Faso.

Abstract

Targeting mosquitoes to target malaria Anopheline mosquitoes transmit the malaria parasite, but the insects themselves are prone to their own infections. Lovett et al. engineered a specific fungal pathogen of anophelines to carry insect-selective toxins. The effectiveness of this fungus for controlling mosquitoes was trialed in near-field conditions in Burkina Faso in a setup called MosquitoSphere. Approximately 75% of wild insecticide-resistant mosquitoes released into the environment became infected with the transgenic fungus, causing population collapse within 45 days. Science , this issue p. 894

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

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4. Insecticide Resistance in African Anopheles Mosquitoes: A Worsening Situation that Needs Urgent Action to Maintain Malaria Control

5. Metarhizium brunneum Blastospore Pathogenesis in Aedes aegypti Larvae: Attack on Several Fronts Accelerates Mortality

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