1. Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.
2. Department of Clinical Neurosciences, Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.
3. Department of Medicine (Neurology), Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto and University Health Network, Toronto, Ontario M5T 2S8, Canada.