Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche-Reference-Cited by-同舟云学术

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

Published:2018-06-29 Issue:6396 Volume:360 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chakrabarti Rumela¹²^ORCID,Celià-Terrassa Toni¹^ORCID,Kumar Sushil²,Hang Xiang¹,Wei Yong¹^ORCID,Choudhury Abrar¹,Hwang Julie¹^ORCID,Peng Jia¹,Nixon Briana³,Grady John J.¹^ORCID,DeCoste Christina¹^ORCID,Gao Jie⁴^ORCID,van Es Johan H.⁵,Li Ming O.³^ORCID,Aifantis Iannis⁴^ORCID,Clevers Hans⁴^ORCID,Kang Yibin¹⁶^ORCID

Affiliation:

1. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

2. Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

4. Department of Pathology, NYU Langone Medical Center, New York City, NY 10016, USA.

5. Hubrecht Institute and University Medical Center Utrecht, Utrecht, Netherlands.

6. Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.

Abstract

Cross-talk in the mammary gland Macrophages engulf damaged and dead cells to clear infection, but they also participate in tissue regeneration. Chakrabarti et al. expand the macrophage repertoire for mammary gland development (see the Perspective by Kannan and Eaves). Mammary gland stem cells secrete the Notch ligand Dll1 and activate Notch signaling, which promotes survival of adjacent macrophages. This stimulates production of Wnt ligands, which signal back to the mammary gland stem cells. This cross-talk plays an important role in coordinating mammary gland development, tissue homeostasis, and, not least, breast cancer. Science , this issue p. eaan4153 ; see also p. 1401

Funder

National Institutes of Health

U.S. Department of Defense

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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