Specialized cutaneous Schwann cells initiate pain sensation-Reference-Cited by-同舟云学术

Specialized cutaneous Schwann cells initiate pain sensation

Published:2019-08-16 Issue:6454 Volume:365 Page:695-699
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Abdo Hind¹^ORCID,Calvo-Enrique Laura¹^ORCID,Lopez Jose Martinez¹^ORCID,Song Jianren²^ORCID,Zhang Ming-Dong¹^ORCID,Usoskin Dmitry¹^ORCID,El Manira Abdeljabbar²,Adameyko Igor³^ORCID,Hjerling-Leffler Jens¹^ORCID,Ernfors Patrik¹^ORCID

Affiliation:

1. Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, Stockholm 17177, Sweden.

2. Department of Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden.

3. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden.

Abstract

A newly discovered cell type for pain perception Pain has been thought to be initiated by activation of free nerve endings without end organs in the skin. In contrast to this paradigm, Abdo et al. discovered a previously unknown meshlike organ covering the skin that senses dangerous environmental stimuli (see the Perspective by Doan and Monk). This organ is built from specialized glial cells located in the epidermal-dermal border and is sufficient and required for initiation of mechanical pain transduction. Science , this issue p. 695 ; see also p. 641

Funder

Wellcome Trust

European Research Council

Karolinska Institutet

Knut och Alice Wallenbergs Stiftelse

Vetenskapsrådet

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. The Sensory Neurons of Touch