Comment on “Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis”-Reference-Cited by-同舟云学术

Comment on “Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis”

Published:2012-06-22 Issue:6088 Volume:336 Page:1506-1506
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Van Kerkhove Maria D.¹,Riley Steven¹,Lipsitch Marc²,Guan Yi³,Monto Arnold S.⁴,Webster Robert G.⁵,Zambon Maria⁶,Nicoll Angus⁷,Peiris J. S. Malik³⁸,Ferguson Neil M.¹

Affiliation:

1. Medical Research Council Centre for Outbreak Analysis and Modelling, Imperial College London, London W2 1PG, UK.

2. Department of Epidemiology, Department of and Immunology and Infectious Diseases, and Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA.

3. Centre of Influenza Research and State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, China.

4. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI USA.

5. Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.

6. Health Protection Agency, London NW9 5HT, UK.

7. European Centre for Disease Prevention and Control, Stockholm, Sweden.

8. School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Abstract

A better understanding of the severity of H5N1 in humans is needed. Wang et al . (Brevia, 23 March 2012, p. 1463; published online 23 February 2012) overinterpret the results of seroprevalence studies and take too little account of underlying uncertainties. Although the true risk of death from H5N1 infection will likely be lower than the 60% of reported laboratory-confirmed cases, there is little evidence of millions of missed infections.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference15 articles.

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3. WHO Update on human cases of highly pathogenic avian influenza A(H5N1) virus infection 2010. Weekly Epidemiologic Record 86 161 (2011); available at www.who.int/wer/2011/wer8617.pdf.

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