An Architectural Framework That May Lie at the Core of the Postsynaptic Density-Reference-Cited by-同舟云学术

An Architectural Framework That May Lie at the Core of the Postsynaptic Density

Published:2006-01-27 Issue:5760 Volume:311 Page:531-535
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Baron Marisa K.¹²³,Boeckers Tobias M.¹²³,Vaida Bianca¹²³,Faham Salem¹²³,Gingery Mari¹²³,Sawaya Michael R.¹²³,Salyer Danielle¹²³,Gundelfinger Eckart D.¹²³,Bowie James U.¹²³

Affiliation:

1. Department of Chemistry and Biochemistry, Molecular Biology Institute and University of California at Los Angeles–U.S. Department of Energy Institute for Genomics and Proteomics, University of California, Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095-1570, USA.

2. Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany.

3. Leibniz Institute for Neurobiology, Post Office Box 1860, D-39008 Magdeburg, Germany.

Abstract

The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn 2+ , which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.

1. Spine architecture and synaptic plasticity

2. Signal-Processing Machines at the Postsynaptic Density

3. Proteomics Analysis of Rat Brain Postsynaptic Density

4. Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry

5. Morphology and molecular composition of isolated postsynaptic junctional structures

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