An Ebola whole-virus vaccine is protective in nonhuman primates-Reference-Cited by-同舟云学术

An Ebola whole-virus vaccine is protective in nonhuman primates

Published:2015-04-24 Issue:6233 Volume:348 Page:439-442
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Marzi Andrea¹,Halfmann Peter²,Hill-Batorski Lindsay²,Feldmann Friederike³,Shupert W. Lesley¹,Neumann Gabriele²,Feldmann Heinz¹,Kawaoka Yoshihiro²⁴⁵

Affiliation:

1. Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

2. Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.

3. Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

4. Department of Microbiology and Immunology, Division of Virology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo.

5. ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan.

Abstract

Ebola virus vaccine candidate As there are so few possibilities for drugs and vaccines that protect against the Ebola virus (EBOV), we need more options. Marzi et al. present initial studies in monkeys of a promising whole Ebola virus vaccine based on a defective form of the virus in which an essential viral gene ( VP30 ) is knocked out. One or two doses of this defective virus, with or without further peroxide inactivation, protected against a lethal challenge of EBOV. In limited immunological analyses, protection correlated with the production of antibodies to the EBOV envelope. Science , this issue p. 439

Funder

NIH

National Institute of Allergy and Infectious Diseases

Health and Labour Sciences Research Grants, Japan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/index.html

2. Ebola virus vaccines: an overview of current approaches

3. Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial