Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring-Reference-Cited by-同舟云学术

Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

Published:2021-08-27 Issue:6558 Volume:373 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lim Ai Ing¹^ORCID,McFadden Taryn¹^ORCID,Link Verena M.¹^ORCID,Han Seong-Ji¹,Karlsson Rose-Marie²,Stacy Apollo¹³^ORCID,Farley Taylor K.¹⁴^ORCID,Lima-Junior Djalma S.¹,Harrison Oliver J.¹^ORCID,Desai Jigar V.⁵^ORCID,Lionakis Michail S.⁵^ORCID,Shih Han-Yu⁶^ORCID,Cameron Heather A.¹²^ORCID,Belkaid Yasmine¹⁷^ORCID

Affiliation:

1. Metaorganism Immunity Section, Laboratory of Immune System Biology and Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Section on Neuroplasticity, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

3. Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, Bethesda, MD 20892, USA.

4. Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK.

5. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

6. Neuro-Immune Regulome Unit, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.

7. NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Mom’s IL-6 rewires baby’s gut immunity Most infections that occur during pregnancy are mild and transient. However, whether such pathogen encounters can shape the long-term trajectory of the offspring’s immune system remains unclear. Lim et al . infected pregnant mice with the common food-borne pathogen Yersinia pseudotuberculosis (YopM) (see the Perspective by Amir and Zeng). Although the infection was maternally restricted and short-lived, the offspring harbored greater numbers of intestinal T helper 17 cells into adulthood. Interleukin-6 (IL-6) mediated this tissue-restricted effect by acting on fetal intestinal epithelium during development. Although offspring from mothers infected with YopM or injected with IL-6 showed enhanced resistance to oral infection with Salmonella Typhimurium, they also exhibited higher susceptibility toward enteric inflammatory disease. —STS

Funder

National Institute of Mental Health

National Institute of General Medical Sciences

Human Frontier Science Program

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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