A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes-Reference-Cited by-同舟云学术

A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes

Published:2022-08-05 Issue:6606 Volume:377 Page:660-666
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bousbaine Djenet¹²³^ORCID,Fisch Laura I.²^ORCID,London Mariya⁴^ORCID,Bhagchandani Preksha²³^ORCID,Rezende de Castro Tiago B.⁴⁵^ORCID,Mimee Mark³⁶⁷^ORCID,Olesen Scott³⁸^ORCID,Reis Bernardo S.⁴^ORCID,VanInsberghe David¹⁹^ORCID,Bortolatto Juliana⁵,Poyet Mathilde³⁸^ORCID,Cheloha Ross W.²^ORCID,Sidney John¹⁰^ORCID,Ling Jingjing²,Gupta Aaron⁴^ORCID,Lu Timothy K.³⁶⁷^ORCID,Sette Alessandro¹⁰¹¹^ORCID,Alm Eric J.³⁸^ORCID,Moon James J.¹²^ORCID,Victora Gabriel D.⁵^ORCID,Mucida Daniel⁴¹³^ORCID,Ploegh Hidde L.²³^ORCID,Bilate Angelina M.³⁴^ORCID

Affiliation:

1. Microbiology Graduate Program, Massachussetts Institute of Technology (MIT), Cambridge, MA, USA.

2. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA, USA.

3. Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.

4. Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.

5. Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.

6. Synthetic Biology Center, MIT, Cambridge, MA, USA.

7. Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA.

8. Department of Biological Engineering, MIT, Cambridge, MA, USA.

9. Department of Civil and Environmental Engineering, MIT, Cambridge, MA, USA.

10. Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.

11. Department of Medicine, University of California, San Diego, CA, USA.

12. Center for Immunology and Inflammatory Diseases and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

13. Howard Hughes Medical Institute, The Rockefeller University, New York NY, USA.

Abstract

The microbiome contributes to the development and maturation of the immune system. In response to commensal bacteria, intestinal CD4 + T lymphocytes differentiate into functional subtypes with regulatory or effector functions. The development of small intestine intraepithelial lymphocytes that coexpress CD4 and CD8αα homodimers (CD4IELs) depends on the microbiota. However, the identity of the microbial antigens recognized by CD4 + T cells that can differentiate into CD4IELs remains unknown. We identified β-hexosaminidase, a conserved enzyme across commensals of the Bacteroidetes phylum, as a driver of CD4IEL differentiation. In a mouse model of colitis, β-hexosaminidase–specific lymphocytes protected against intestinal inflammation. Thus, T cells of a single specificity can recognize a variety of abundant commensals and elicit a regulatory immune response at the intestinal mucosa.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference57 articles.

1. Homeostatic Immunity and the Microbiota

2. Intestinal Commensal Microbes as Immune Modulators

3. Microbial modulation of intestinal T helper cell responses and implications for disease and therapy

4. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

5. Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells

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