Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex-Reference-Cited by-同舟云学术

Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Published:2023-10-13 Issue:6667 Volume:382 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chartrand Thomas¹^ORCID,Dalley Rachel¹^ORCID,Close Jennie¹^ORCID,Goriounova Natalia A.²^ORCID,Lee Brian R.¹^ORCID,Mann Rusty¹^ORCID,Miller Jeremy A.¹^ORCID,Molnar Gabor³^ORCID,Mukora Alice¹^ORCID,Alfiler Lauren¹^ORCID,Baker Katherine¹^ORCID,Bakken Trygve E.¹^ORCID,Berg Jim¹^ORCID,Bertagnolli Darren¹^ORCID,Braun Thomas⁴^ORCID,Brouner Krissy¹^ORCID,Casper Tamara¹^ORCID,Csajbok Eva Adrienn³^ORCID,Dee Nick¹^ORCID,Egdorf Tom¹^ORCID,Enstrom Rachel¹^ORCID,Galakhova Anna A.²^ORCID,Gary Amanda¹^ORCID,Gelfand Emily¹^ORCID,Goldy Jeff¹^ORCID,Hadley Kristen¹^ORCID,Heistek Tim S.²,Hill DiJon¹^ORCID,Jorstad Nik¹^ORCID,Kim Lisa¹^ORCID,Kocsis Agnes Katalin³^ORCID,Kruse Lauren¹^ORCID,Kunst Michael¹^ORCID,Leon Gabriela¹,Long Brian¹^ORCID,Mallory Matthew¹^ORCID,McGraw Medea¹^ORCID,McMillen Delissa¹^ORCID,Melief Erica J.⁵^ORCID,Mihut Norbert³,Ng Lindsay¹^ORCID,Nyhus Julie¹^ORCID,Oláh Gáspár³^ORCID,Ozsvár Attila³,Omstead Victoria¹^ORCID,Peterfi Zoltan³,Pom Alice¹^ORCID,Potekhina Lydia¹^ORCID,Rajanbabu Ramkumar¹^ORCID,Rozsa Marton³^ORCID,Ruiz Augustin¹^ORCID,Sandle Joanna³,Sunkin Susan M.¹^ORCID,Szots Ildiko³^ORCID,Tieu Michael¹^ORCID,Toth Martin³^ORCID,Trinh Jessica¹^ORCID,Vargas Sara¹,Vumbaco David¹^ORCID,Williams Grace¹^ORCID,Wilson Julia¹,Yao Zizhen¹^ORCID,Barzo Pal⁶^ORCID,Cobbs Charles⁷^ORCID,Ellenbogen Richard G.⁸^ORCID,Esposito Luke¹^ORCID,Ferreira Manuel⁸,Gouwens Nathan W.¹,Grannan Benjamin⁸^ORCID,Gwinn Ryder P.⁷^ORCID,Hauptman Jason S.⁸,Jarsky Tim¹^ORCID,Keene C. Dirk⁵^ORCID,Ko Andrew L.⁸^ORCID,Koch Christof¹^ORCID,Ojemann Jeffrey G.⁸^ORCID,Patel Anoop⁸,Ruzevick Jacob⁸,Silbergeld Daniel L.⁸,Smith Kimberly¹^ORCID,Sorensen Staci A.¹,Tasic Bosiljka¹^ORCID,Ting Jonathan T.¹⁹¹⁰^ORCID,Waters Jack¹^ORCID,de Kock Christiaan P.J.²^ORCID,Mansvelder Huib D.²^ORCID,Tamas Gabor³^ORCID,Zeng Hongkui¹^ORCID,Kalmbach Brian¹⁹^ORCID,Lein Ed S.¹⁸^ORCID

Affiliation:

1. Allen Institute for Brain Science, Seattle, WA, USA.

2. Center for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands.

3. Research Group for Cortical Microcircuits of the Hungarian Academy of Science, University of Szeged, Szeged, Hungary.

4. byte physics, Berlin, Germany.

5. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.

6. Department of Neurosurgery, University of Szeged, Szeged, Hungary.

7. Swedish Neuroscience Institute, Seattle, WA, USA.

8. Department of Neurological Surgery, University of Washington, Seattle, WA, USA.

9. Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.

10. Washington National Primate Research Center, University of Washington, Seattle, WA, USA.

Abstract

Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1. Subclass and subtype comparisons showed stronger transcriptomic differences in human L1 and were correlated with strong morphoelectric variability along dimensions distinct from mouse L1 variability. Accompanied by greater layer thickness and other cytoarchitecture changes, these findings suggest that L1 has diverged in evolution, reflecting the demands of regulating the expanded human neocortical circuit.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.adf0805

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