A Common Pathway for a Rare Disease?-Reference-Cited by-同舟云学术

A Common Pathway for a Rare Disease?

Published:2013-12-20 Issue:6165 Volume:342 Page:1453-1454
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Vafai Scott B.¹²³,Mootha Vamsi K.¹²³

Affiliation:

1. Howard Hughes Medical Institute, Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

2. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

3. Broad Institute, MA 02141, USA.

Abstract

A rare childhood disorder caused by mitochondrial dysfunction is treated by the drug rapamycin in a mouse model of the disease. [Also see Report by Johnson et al. ]

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference11 articles.

1. SUBACUTE NECROTIZING ENCEPHALOMYELOPATHY IN AN INFANT

2. mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

3. Mitochondrial disorders as windows into an ancient organelle

4. mTOR is a key modulator of ageing and age-related disease

5. Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

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