1. Department of Medicine, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
2. Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
3. Translational Laboratory in Genetic Medicine (TLGM), Department of Medicine, National University of Singapore, and Agency for Science, Technology and Research (A*STAR), Singapore 117609, Singapore.