Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior-Reference-Cited by-同舟云学术

Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior

Published:2006-10-06 Issue:5796 Volume:314 Page:140-143
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chen Zhe-Yu¹²³⁴⁵,Jing Deqiang¹²³⁴⁵,Bath Kevin G.¹²³⁴⁵,Ieraci Alessandro¹²³⁴⁵,Khan Tanvir¹²³⁴⁵,Siao Chia-Jen¹²³⁴⁵,Herrera Daniel G.¹²³⁴⁵,Toth Miklos¹²³⁴⁵,Yang Chingwen¹²³⁴⁵,McEwen Bruce S.¹²³⁴⁵,Hempstead Barbara L.¹²³⁴⁵,Lee Francis S.¹²³⁴⁵

Affiliation:

1. Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA.

2. Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

3. Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA.

4. School of Medicine, Shandong University, Jinan, Shandong 250012, People's Republic of China.

5. Gene Targeting Facility, The Rockefeller University, New York, NY 10021, USA.

Abstract

A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF Met/Met ) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF Met was expressed in brain at normal levels, but its secretion from neurons was defective. When placed in stressful settings, BDNF Met/Met mice exhibited increased anxiety-related behaviors that were not normalized by the antidepressant, fluoxetine. A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits

2. BDNF Val66Met Allele Is Associated with Reduced Hippocampal Volume in Healthy Subjects

3. The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology

4. Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation

5. Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance

Cited by 1150 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Association of open skill exercise and long-chain polyunsaturated fatty acid intake with brain volume changes among older community-dwelling Japanese individuals;Archives of Gerontology and Geriatrics;2025-01

2. Late-onset major depressive disorder: exploring the therapeutic potential of enhancing cerebral brain-derived neurotrophic factor expression through targeted microRNA delivery;Translational Psychiatry;2024-09-03

3. Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats;npj Parkinson's Disease;2024-08-23

4. The relevance of BDNF for neuroprotection and neuroplasticity in multiple sclerosis;Frontiers in Neurology;2024-08-01

5. Sex differences in neural projections of fear memory processing in mice and humans;Science Advances;2024-07-12