Affiliation:
1. The Robinson Research Institute and School of Paediatrics and Reproductive Health, The University of Adelaide, Level 3, Medical School, South Adelaide, SA, 5005 Australia.
Abstract
At fertilization, the gametes endow the embryo with a genomic blueprint, the integrity of which is affected by the age and environmental exposures of both parents. Recent studies reveal that parental history and experiences also exert effects through epigenomic information not contained in the DNA sequence, including variations in sperm and oocyte cytosine methylation and chromatin patterning, noncoding RNAs, and mitochondria. Transgenerational epigenetic effects interact with conditions at conception to program the developmental trajectory of the embryo and fetus, ultimately affecting the lifetime health of the child. These insights compel us to revise generally held notions to accommodate the prospect that biological parenting commences well before birth, even prior to conception.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
244 articles.
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