Genetic behavioral screen identifies an orphan anti-opioid system-Reference-Cited by-同舟云学术

Genetic behavioral screen identifies an orphan anti-opioid system

Published:2019-09-20 Issue:6459 Volume:365 Page:1267-1273
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wang Dandan¹^ORCID,Stoveken Hannah M.¹,Zucca Stefano¹^ORCID,Dao Maria¹,Orlandi Cesare¹^ORCID,Song Chenghui¹^ORCID,Masuho Ikuo¹,Johnston Caitlin¹^ORCID,Opperman Karla J.¹,Giles Andrew C.¹^ORCID,Gill Matthew S.²^ORCID,Lundquist Erik A.³^ORCID,Grill Brock¹^ORCID,Martemyanov Kirill A.¹^ORCID

Affiliation:

1. Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

2. Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.

3. Department of Molecular Biosciences, The University of Kansas, Lawrence, KS 66045, USA.

Abstract

Worms yield opioid receptor insight The µ-opioid receptor (MOR) is the target of pain-reducing drugs, including morphine and the potent synthetic opioid fentanyl. Better understanding of the receptor system is needed to suppress potentially deadly side effects and manage addiction potential. Wang et al. used a screen in the worm Caenorhabditis elegans to find genes that influenced MOR function (see the Perspective by Mercer Lindsay and Scherrer). They found another receptor called GPR139, loss of which enhanced effects of morphine in mice but reduced withdrawal effects. GPR139 could be a target to improve safety or efficacy of opioid therapy. Science , this issue p. 1267 ; see also p. 1246

Funder

National Institute on Drug Abuse

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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