Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages-Reference-Cited by-同舟云学术

Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages

Published:2015-09-04 Issue:6252 Volume:349 Page:1120-1124
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schumacher Maria A.¹,Tonthat Nam K.¹,Lee Jeehyun¹,Rodriguez-Castañeda Fernando A.²,Chinnam Naga Babu¹,Kalliomaa-Sanford Anne K.²,Ng Irene W.²,Barge Madhuri T.²,Shaw Porsha L. R.¹,Barillà Daniela²

Affiliation:

1. Department of Biochemistry, Duke University School of Medicine, 243 Nanaline H. Duke, Box 3711, Durham, NC 27710, USA.

2. Department of Biology, University of York, York YO10 5DD, UK.

Abstract

Plasmid partitioning superstructure system Partitioning and sharing DNA between dividing cells is critical for all domains of life. Prokaryotes must share certain plasmids as well as their genomic DNA to survive. Schumacher et al. studied the partition system that segregates a conjugative plasmid in the prokaryote Sulfolobus. The system consists of three proteins. AspA spreads along the plasmid DNA to create a protein-DNA superhelix. The ParA motor protein is linked to the protein-DNA superhelix through the ParB protein, which has structural similarities to eukaryotic centromere segregating proteins. Science , this issue p. 1120

Funder

NIH

UK Biotechnology and Biological Sciences Research Council

Leverhulme Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

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