Evolution of protein phosphorylation across 18 fungal species-Reference-Cited by-同舟云学术

Evolution of protein phosphorylation across 18 fungal species

Published:2016-10-14 Issue:6309 Volume:354 Page:229-232
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Studer Romain A.¹,Rodriguez-Mias Ricard A.²,Haas Kelsey M.²,Hsu Joanne I.²,Viéitez Cristina³⁴,Solé Carme³,Swaney Danielle L.²,Stanford Lindsay B.²,Liachko Ivan²,Böttcher René³,Dunham Maitreya J.²,de Nadal Eulàlia³,Posas Francesc³,Beltrao Pedro¹⁴,Villén Judit²

Affiliation:

1. European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

2. Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

3. Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, E-08003 Barcelona, Spain.

4. EMBL, Genome Biology Unit, 69117 Heidelberg, Germany.

Abstract

Phosphorylation and fungal evolution Phosphorylation after transcription modifies the activity of proteins. To understand how phosphorylation sites have evolved, Studer et al. studied a range of fungal species (see the Perspective by Matalon et al. ). Only a few sites were apparently present in the common ancestor of all 18 species investigated. Evolutionary age appeared to predict the potential functional importance of specific conserved phosphosites. Science , this issue p. 229 ; see also p. 176

Funder

Ellison Medical Foundation

Amgen scholarship

Mary Gates scholarship

NSF

Human Frontier Science Program

European Research Council

Rita Allen Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary