Gene Regulation in the Third Dimension-Reference-Cited by-同舟云学术

Gene Regulation in the Third Dimension

Published:2008-03-28 Issue:5871 Volume:319 Page:1793-1794
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dekker Job¹

Affiliation:

1. Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605–0103, USA.

Abstract

Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease

2. Remote control of gene transcription

3. Capturing Chromosome Conformation

4. Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

5. Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression

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