Differential Antigen Processing by Dendritic Cell Subsets in Vivo-Reference-Cited by-全球学者库

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

Published:2007-01-05 Issue:5808 Volume:315 Page:107-111
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dudziak Diana¹²³⁴,Kamphorst Alice O.¹²³⁴,Heidkamp Gordon F.¹²³⁴,Buchholz Veit R.¹²³⁴,Trumpfheller Christine¹²³⁴,Yamazaki Sayuri¹²³⁴,Cheong Cheolho¹²³⁴,Liu Kang¹²³⁴,Lee Han-Woong¹²³⁴,Park Chae Gyu¹²³⁴,Steinman Ralph M.¹²³⁴,Nussenzweig Michel C.¹²³⁴

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA.

2. Laboratory of Cellular Immunology and Physiology, The Rockefeller University, New York, NY 10021, USA.

3. Department of Biochemistry, College of Sciences, Yonsei University, Seoul 120-749, Korea.

4. Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 USA.

Abstract

Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8 + DCs that express the cell surface protein CD205, CD8 – DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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