Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses-Reference-Cited by-同舟云学术

Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses

Published:2012-01-20 Issue:6066 Volume:335 Page:344-348
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Narni-Mancinelli Emilie¹²³,Jaeger Baptiste N.¹²³,Bernat Claire¹²³,Fenis Aurore¹²³,Kung Sam⁴,De Gassart Aude¹²³,Mahmood Sajid⁴,Gut Marta⁵,Heath Simon C.⁵,Estellé Jordi⁵,Bertosio Elodie¹²³,Vely Frédéric¹²³⁶,Gastinel Louis N.⁷,Beutler Bruce⁸,Malissen Bernard¹²³,Malissen Marie¹²³,Gut Ivo G.⁵,Vivier Eric¹²³⁶,Ugolini Sophie¹²³⁹

Affiliation:

1. Centre d’Immunologie de Marseille-Luminy, Aix-Marseille University, Campus de Luminy case 906, 13288 Marseille, France.

2. INSERM U1104, 13288 Marseille, France.

3. CNRS, UMR7280, 13288 Marseille, France.

4. Apotex Center, Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.

5. Centre Nacional d'Anàlisi Genòmica (CNAG), Parc Científic de Barcelona, 08028 Barcelona, Spain.

6. Assistance Publique—Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France.

7. INSERM U850, University of Limoges, University Hospital Limoges, 87060 Limoges, France.

8. Center for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

9. Institut Paoli-Calmettes, Centre de Lutte Contre le Cancer, 13273 Marseille, France.

Abstract

Natural Killer Controls Cytolytic natural killer (NK) cells participate in both antimicrobial and antitumor immunity. Their responsiveness is tuned through signals received through a variety of inhibitory and activating receptors expressed on their cell surface. Narni-Mancinelli et al. (p. 344 ) now show that signaling through the activating receptor NKp46 paradoxically keeps NK cell responses in check. NK cells from mice with disrupted NKp46 expression were hyperresponsive to stimulation and better protected against viral infection. NK cell responses, which are part of the early response to infection, may thus need to be carefully tuned to ensure optimal initiation of adaptive immunity and formation of protective long-lived memory cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Keeping NK cells in highly regulated antiviral warfare

2. Interplay of natural killer cells and their receptors with the adaptive immune response

3. Innate or Adaptive Immunity? The Example of Natural Killer Cells

4. Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

5. Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

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