Timing the SARS-CoV-2 index case in Hubei province-Reference-Cited by-同舟云学术

Timing the SARS-CoV-2 index case in Hubei province

Published:2021-04-23 Issue:6540 Volume:372 Page:412-417
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pekar Jonathan¹²^ORCID,Worobey Michael³^ORCID,Moshiri Niema⁴^ORCID,Scheffler Konrad⁵^ORCID,Wertheim Joel O.⁶^ORCID

Affiliation:

1. Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA 92093, USA.

2. Department of Biomedical Informatics, University of California San Diego, La Jolla, CA 92093, USA.

3. Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA.

4. Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.

5. Illumina, Inc., San Diego, CA 92122, USA.

6. Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

Backtracking a pandemic Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have had a history of abortive human infections before a variant established a productive enough infection to create a transmission chain with pandemic potential. Therefore, the Wuhan cluster of infections identified in late December of 2019 may not have represented the initiating event. Pekar et al. used genome data collected from the early cases of the COVID-19 pandemic combined with molecular clock inference and epidemiological simulation to estimate when the most successful variant gained a foothold in humans. This analysis pushes human-to-human transmission back to mid-October to mid-November of 2019 in Hubei Province, China, with a likely short interval before epidemic transmission was initiated. Science , this issue p. 412

Funder

National Science Foundation

David and Lucile Packard Foundation

National Institute of Allergy and Infectious Diseases

U.S. National Library of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference54 articles.

1. A Novel Coronavirus from Patients with Pneumonia in China, 2019

2. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

3. World Health Organization “Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19)” (World Health Organization 2020); www.who.int/publications/i/item/report-of-the-who-china-joint-mission-on-coronavirus-disease-2019-(covid-19).

4. The impact of the COVID-19 epidemic on tuberculosis control in China

5. World Health Organization “WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020” (World Health Organization 2020); www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020.

Cited by 107 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quantitatively assessing early detection strategies for mitigating COVID-19 and future pandemics;Nature Communications;2023-12-20

2. An ncRNA transcriptomics-based approach to design siRNA molecules against SARS-CoV-2 double membrane vesicle formation and accessory genes;BMC Infectious Diseases;2023-12-12

3. The impact of COVID-19 on antibiotic resistance and clinical outcomes among critically ill patients;American Journal of Infection Control;2023-12

4. Ecological and Evolutionary Insights About Emerging Infectious Diseases from the COVID-19 Pandemic;Annual Review of Ecology, Evolution, and Systematics;2023-11-02

5. Development of an EBOV MiniG plus system as an advanced tool for anti-Ebola virus drug screening;Heliyon;2023-11