Multistep Control of Pituitary Organogenesis-Reference-Cited by-同舟云学术

Multistep Control of Pituitary Organogenesis

Published:1997-12-05 Issue:5344 Volume:278 Page:1809-1812
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sheng Hui Z.¹²³⁴⁵,Moriyama Kenji¹²³⁴⁵,Yamashita Tsuyoshi¹²³⁴⁵,Li Hung¹²³⁴⁵,Potter S. Steven¹²³⁴⁵,Mahon Kathleen A.¹²³⁴⁵,Westphal Heiner¹²³⁴⁵

Affiliation:

1. H. Z. Sheng, T. Yamashita, H. Westphal, Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

2. K. Moriyama, Department of Anatomy, Shimane Medical University, 89-1 Enya Izumo 693, Japan.

3. H. Li, Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.

4. S. S. Potter, Division of Developmental Biology, Children's Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

5. K. A. Mahon, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Lhx3 and Lhx4 ( Gsh4 ), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps—first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

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