ACD toxin–produced actin oligomers poison formin-controlled actin polymerization-Reference-Cited by-同舟云学术

ACD toxin–produced actin oligomers poison formin-controlled actin polymerization

Published:2015-07-31 Issue:6247 Volume:349 Page:535-539
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Heisler David B.¹²,Kudryashova Elena¹,Grinevich Dmitry O.¹,Suarez Cristian³,Winkelman Jonathan D.³,Birukov Konstantin G.⁴,Kotha Sainath R.⁵,Parinandi Narasimham L.⁵,Vavylonis Dimitrios⁶,Kovar David R.³⁷,Kudryashov Dmitri S.¹²

Affiliation:

1. Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.

2. The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA.

3. Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.

4. Section of Pulmonary and Critical Care and Lung Injury Center, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

5. Lipid Signaling and Lipidomics Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

6. Department of Physics, Lehigh University, Bethlehem, PA 18015, USA.

7. Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.

Abstract

A little toxin can do a lot The actin cross-linking domain (ACD) is an actin-specific toxin produced by several bacterial pathogens. Heisler et al. discovered that ACD's pathogenic mechanism involves a highly unusual toxicity amplification cascade. Rather than directly inactivating the actin cytoskeleton, ACD blocks the activity of formins, actin regulatory proteins that play crucial roles in numerous cellular activities. ACD is exceptionally potent, even though its substrate is the most abundant protein of a eukaryotic cell: actin. Science , this issue p. 535

Funder

NIH

American Heart Association

Ohio State University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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