Competition between engrams influences fear memory formation and recall-Reference-Cited by-同舟云学术

Competition between engrams influences fear memory formation and recall

Published:2016-07-22 Issue:6297 Volume:353 Page:383-387
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rashid Asim J.¹²³⁴,Yan Chen¹²³⁴,Mercaldo Valentina¹²³⁴,Hsiang Hwa-Lin (Liz)¹²³⁴,Park Sungmo¹²³⁴,Cole Christina J.¹²³⁴,De Cristofaro Antonietta¹,Yu Julia¹,Ramakrishnan Charu⁵,Lee Soo Yeun⁵,Deisseroth Karl⁵,Frankland Paul W.¹²³⁴,Josselyn Sheena A.¹²³⁴

Affiliation:

1. Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

2. Department of Psychology, University of Toronto, Toronto, ON M5G 3G3, Canada.

3. Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.

4. Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada.

5. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

Abstract

How to link and separate memories Engrams are the changes in brain tissue that store single memories. Neuroscientists can localize and manipulate them, but until now, little was known about how multiple engrams interact to influence memories. Rashid et al. examined how neural assemblies in an area called the lateral amygdala interact. If two frightening events occurred within 6 hours, the same set of neurons was used to express fear memories for both events. However, if the events were separated by 24 hours, distinct memory traces were formed. Science , this issue p. 383

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Brain Canada

Brain and Behavior Research Foundation

National Institute of Mental Health

National Institute on Drug Abuse

Wiegers Family Fund

Howard Hughes Medical Institute

U.S. Army Research Laboratory

Defense Advanced Research Projects Agency

Publisher