An Essential Role for Ectodomain Shedding in Mammalian Development-Reference-Cited by-同舟云学术

An Essential Role for Ectodomain Shedding in Mammalian Development

Published:1998-11-13 Issue:5392 Volume:282 Page:1281-1284
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Peschon Jacques J.¹,Slack Jennifer L.¹,Reddy Pranitha¹,Stocking Kim L.¹,Sunnarborg Susan W.¹,Lee David C.¹,Russell William E.¹,Castner Beverly J.¹,Johnson Richard S.¹,Fitzner Jeffrey N.¹,Boyce Rogely W.¹,Nelson Nicole¹,Kozlosky Carl J.¹,Wolfson Martin F.¹,Rauch Charles T.¹,Cerretti Douglas Pat¹,Paxton Raymond J.¹,March Carl J.¹,Black Roy A.¹

Affiliation:

1. J. J. Peschon, J. L. Slack, P. Reddy, K. L. Stocking, B. J. Castner, R. S. Johnson, J. N. Fitzner, N. Nelson, C. J. Kozlosky, M. F. Wolfson, C. T. Rauch, D. P. Cerretti, R. J. Paxton, C. J. March, and R. A. Black are with Immunex Corporation, 51 University Street, Seattle, WA 98101, USA. S. W. Sunnarborg and D. C. Lee are in the Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599–7260, USA. W. E. Russell is in the Departments of Pediatrics and Cell Biology,...

Abstract

The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-α converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-α (TNFα) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the l -selectin adhesion molecule, and transforming growth factor-α (TGFα). The phenotype of mice lacking TACE suggests an essential role for soluble TGFα in normal development and emphasizes the importance of protein ectodomain shedding in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

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