Global Epigenomic Reconfiguration During Mammalian Brain Development

Author:

Lister Ryan12,Mukamel Eran A.3,Nery Joseph R.1,Urich Mark1,Puddifoot Clare A.3,Johnson Nicholas D.3,Lucero Jacinta3,Huang Yun4,Dwork Andrew J.56,Schultz Matthew D.17,Yu Miao8,Tonti-Filippini Julian2,Heyn Holger9,Hu Shijun10,Wu Joseph C.10,Rao Anjana4,Esteller Manel911,He Chuan8,Haghighi Fatemeh G.5,Sejnowski Terrence J.31213,Behrens M. Margarita3,Ecker Joseph R.113

Affiliation:

1. Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

2. Plant Energy Biology [Australian Research Council Center of Excellence (CoE)] and Computational Systems Biology (Western Australia CoE), School of Chemistry and Biochemistry, The University of Western Australia, Perth, WA 6009, Australia.

3. Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

4. La Jolla Institute for Allergy and Immunology and Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.

5. Department of Psychiatry, Columbia University and The New York State Psychiatric Institute, New York, NY 10032, USA.

6. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

7. Bioinformatics Program, University of California at San Diego, La Jolla, CA 92093, USA.

8. Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.

9. Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona 08907, Spain.

10. Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

11. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.

12. Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92037, USA.

13. Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Epigenetic Brainscape Epigenetic modifications and their potential changes during development are of high interest, but few studies have characterized such differences. Lister et al. ( 1237905 , published online 4 July; see the Perspective by Gabel and Greenberg ) report whole-genome base-resolution analysis of DNA cytosine modifications and transcriptome analysis in the frontal cortex of human and mouse brains at multiple developmental stages. The high-resolution mapping of DNA cytosine methylation (5mC) and one of its oxidation derivatives (5hmC) at key developmental stages provides a comprehensive resource covering the temporal dynamics of these epigenetic modifications in neurons compared to glia. The data suggest that methylation marks are dynamic during brain development in both humans and mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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