Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection-Reference-Cited by-同舟云学术

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

Published:2016-08-19 Issue:6301 Volume:353 Page:823-826
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Stettler Karin¹,Beltramello Martina¹,Espinosa Diego A.²,Graham Victoria³,Cassotta Antonino⁴⁵,Bianchi Siro¹,Vanzetta Fabrizia¹,Minola Andrea¹,Jaconi Stefano¹,Mele Federico⁴,Foglierini Mathilde⁴,Pedotti Mattia⁴,Simonelli Luca⁴,Dowall Stuart³,Atkinson Barry³,Percivalle Elena⁶,Simmons Cameron P.⁷⁸⁹,Varani Luca⁴,Blum Johannes¹⁰¹¹,Baldanti Fausto⁶,Cameroni Elisabetta¹,Hewson Roger³,Harris Eva²,Lanzavecchia Antonio⁴⁵,Sallusto Federica⁴,Corti Davide¹

Affiliation:

1. Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland.

2. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.

3. National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire, UK.

4. Institute for Research in Biomedicine, Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.

5. Institute for Microbiology, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.

6. Molecular Virology Unit, Microbiology and Virology Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.

7. Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, UK.

8. Oxford University Clinical Research Unit, Center for Tropical Medicine, Ho Chi Minh City, Vietnam.

9. Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, 792 Elizabeth Street, Melbourne VIC 3000, Australia.

10. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.

11. University of Basel, Petersgraben 4, 4031 Basel, Switzerland.

Abstract

Characterizing the Zika virus antibody response Given the public health emergency that Zika virus poses, scientists are seeking to understand the Zika-specific immune response. Stettler et al. analyzed 119 monoclonal antibodies isolated from four donors that were infected with Zika virus during the present epidemic, including two individuals that had previously been infected with dengue virus, another member of the flavivirus family. Neutralizing antibodies primarily recognized the envelope protein domain III (EDIII) or quaternary epitopes on the intact virus, and an EDIII-targeted antibody protected mice against lethal infection. Some EDI/II-targeting antibodies cross-reacted with dengue virus in vitro and could enhance disease in dengue-infected mice. Whether dengue and Zika virus antibodies cross-react in humans remains to be tested. Science , this issue p. 823

Funder

European Union

European Research Council

Swiss National Science Foundation

U.S. National Institutes of Health

Ministero della Salute, Fondazione IRCCS Policlinico San Matteo, Ricerca Corrente

Helmut Horten Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.