Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis-Reference-Cited by-同舟云学术

Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

Published:2012-06-08 Issue:6086 Volume:336 Page:1314-1317
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Iliev Iliyan D.¹,Funari Vincent A.²³,Taylor Kent D.²,Nguyen Quoclinh²,Reyes Christopher N.¹,Strom Samuel P.²,Brown Jordan²,Becker Courtney A.¹,Fleshner Phillip R.⁴,Dubinsky Marla¹⁵,Rotter Jerome I.²,Wang Hanlin L.⁶,McGovern Dermot P. B.¹²,Brown Gordon D.⁷,Underhill David M.¹⁶⁸

Affiliation:

1. Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

2. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

3. Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

4. Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

5. Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

6. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

7. Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences and The Aberdeen Fungal Group, University of Aberdeen, Aberdeen AB24 2ZD, UK.

8. Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Abstract

The Mycobiome In the past few years, much attention has been given to the trillions of bacterial inhabitants in our guts and the myriad of ways in which they influence our overall health. But what about fungi? Iliev et al. (p. 1314 ) now report that mice and humans, along with several other mammals, contain a resident intestinal population of fungi. Deletion of Dectin-1, which acts as a major innate immune sensor for fungi, led to enhanced susceptibility and worse pathology in a chemically induced model of colitis in mice. A polymorphism in the gene that encodes Dectin-1 has been observed in patients with ulcerative colitis, which hints that, besides the traditional bacterial microbiome, alterations in the “mycobiome” may also play a role in health and disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae

2. A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

3. NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

4. Enterotypes of the human gut microbiome

5. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

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