Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident-Reference-Cited by-同舟云学术

Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident

Published:2021-05-14 Issue:6543 Volume:372 Page:725-729
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yeager Meredith¹²^ORCID,Machiela Mitchell J.¹^ORCID,Kothiyal Prachi¹³^ORCID,Dean Michael¹²^ORCID,Bodelon Clara¹^ORCID,Suman Shalabh¹²,Wang Mingyi¹²^ORCID,Mirabello Lisa¹,Nelson Chase W.⁴⁵^ORCID,Zhou Weiyin¹²^ORCID,Palmer Cameron¹²,Ballew Bari¹²,Colli Leandro M.¹⁶^ORCID,Freedman Neal D.¹^ORCID,Dagnall Casey¹²^ORCID,Hutchinson Amy¹²^ORCID,Vij Vibha¹^ORCID,Maruvka Yosi⁷⁸,Hatch Maureen¹,Illienko Iryna⁹^ORCID,Belayev Yuri⁹^ORCID,Nakamura Nori¹⁰^ORCID,Chumak Vadim⁹^ORCID,Bakhanova Elena⁹^ORCID,Belyi David⁹^ORCID,Kryuchkov Victor¹¹^ORCID,Golovanov Ivan¹¹,Gudzenko Natalia⁹^ORCID,Cahoon Elizabeth K.¹^ORCID,Albert Paul¹,Drozdovitch Vladimir¹^ORCID,Little Mark P.¹^ORCID,Mabuchi Kiyohiko¹^ORCID,Stewart Chip⁷^ORCID,Getz Gad⁷⁸¹²¹³^ORCID,Bazyka Dimitry⁹^ORCID,Berrington de Gonzalez Amy¹^ORCID,Chanock Stephen J.¹^ORCID

Affiliation:

1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.

2. Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.

3. SymbioSeq LLC, Arlington, VA 20148, USA.

4. Biodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan.

5. Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA.

6. Department of Medical Imaging, Hematology, and Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, 14049-900, Brazil.

7. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

8. Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.

9. National Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.

10. Department of Molecular Biosciences, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732-0815, Japan.

11. Burnasyan Federal Medical and Biophysical Centre, 46 Zhivopisnaya Street, Moscow, 123182, Russia.

12. Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

13. Harvard Medical School, Boston, MA 02115, USA.

Abstract

Genomics of radiation-induced damage The potential adverse effects of exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, as well as long-term sequelae such as increased risk of cancer. There have been a few studies examining transgenerational risks of radiation exposure but the results have been inconclusive. Morton et al. analyzed papillary thyroid tumors, normal thyroid tissue, and blood from hundreds of survivors of the Chernobyl nuclear accident and compared them against those of unexposed patients. The findings offer insight into the process of radiation-induced carcinogenesis and characteristic patterns of DNA damage associated with environmental radiation exposure. In a separate study, Yeager et al. analyzed the genomes of 130 children and parents from families in which one or both parents had experienced gonadal radiation exposure related to the Chernobyl accident and the children were conceived between 1987 and 2002. Reassuringly, the authors did not find an increase in new germline mutations in this population. Science , this issue p. eabg2538 , p. 725

Funder

National Cancer Institute

American Museum of Natural History

Gerstner Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. Benefits and limitations of genome-wide association studies

2. Rate of de novo mutations and the importance of father’s age to disease risk

3. Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation