Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus-Reference-Cited by-同舟云学术

Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus

Published:2003-11-28 Issue:5650 Volume:302 Page:1569-1571
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Weigel Linda M.¹²³⁴,Clewell Don B.¹²³⁴,Gill Steven R.¹²³⁴,Clark Nancye C.¹²³⁴,McDougal Linda K.¹²³⁴,Flannagan Susan E.¹²³⁴,Kolonay James F.¹²³⁴,Shetty Jyoti¹²³⁴,Killgore George E.¹²³⁴,Tenover Fred C.¹²³⁴

Affiliation:

1. Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

2. Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.

3. The Institute for Genomic Research, Rockville, MD 20850, USA.

4. J. Craig Venter Science Foundation Joint Technology Center, Rockville, MD 20850, USA.

Abstract

Vancomycin is usually reserved for treatment of serious infections, including those caused by multidrug-resistant Staphylococcus aureus . A clinical isolate of S. aureus with high-level resistance to vancomycin (minimal inhibitory concentration = 1024 μg/ml) was isolated in June 2002. This isolate harbored a 57.9-kilobase multiresistance conjugative plasmid within which Tn 1546 ( vanA ) was integrated. Additional elements on the plasmid encoded resistance to trimethoprim ( dfrA ), β-lactams ( blaZ ), aminoglycosides ( aacA-aphD ), and disinfectants ( qacC ). Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn 1546 from a co-isolate of Enterococcus faecalis .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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