BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination-Reference-Cited by-同舟云学术

BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination

Published:2024-03-29 Issue:6690 Volume:383 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fromsa Abebe¹²^ORCID,Willgert Katriina³^ORCID,Srinivasan Sreenidhi⁴⁵⁶^ORCID,Mekonnen Getnet⁷^ORCID,Bedada Wegene⁷,Gumi Balako¹,Lakew Matios⁷,Tadesse Biniam⁷,Bayissa Berecha¹^ORCID,Sirak Asegedech⁷,Girma Abdela Musse¹^ORCID,Gebre Solomon⁷,Chibssa Tesfaye⁷,Veerasami Maroudam⁸^ORCID,Vordermeier H. Martin⁹,Bakker Douwe⁴¹⁰¹¹^ORCID,Berg Stefan⁹^ORCID,Ameni Gobena¹¹²^ORCID,Juleff Nick¹³^ORCID,de Jong Mart C. M.¹⁴^ORCID,Wood James³^ORCID,Conlan Andrew³^ORCID,Kapur Vivek⁴⁵^ORCID

Affiliation:

1. Aklilu Lemma Institutes of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.

2. College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.

3. Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, UK.

4. Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, USA.

5. Department of Animal Science, The Pennsylvania State University, University Park, PA, USA.

6. The Global Health Initiative, Henry Ford Health, Detroit, MI, USA.

7. Animal Health Institute, Sebeta, Ethiopia.

8. CisGen Biotech Discoveries, Chennai, India.

9. Animal and Plant Health Agency, Weybridge, UK.

10. Technical Consultant and Independent Researcher, Lelystad, Netherlands.

11. Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.

12. Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, United Arab Emirates University, United Arab Emirates.

13. The Bill & Melinda Gates Foundation Seattle, WA, USA.

14. Quantitative Veterinary Epidemiology Group, Wageningen UR, The Netherlands.

Abstract

Bacillus Calmette-Guérin (BCG) is a routinely used vaccine for protecting children against Mycobacterium tuberculosis that comprises attenuated Mycobacterium bovis . BCG can also be used to protect livestock against M. bovis ; however, its effectiveness has not been quantified for this use. We performed a natural transmission experiment to directly estimate the rate of transmission to and from vaccinated and unvaccinated calves over a 1-year exposure period. The results show a higher indirect efficacy of BCG to reduce transmission from vaccinated animals that subsequently become infected [74%; 95% credible interval (CrI): 46 to 98%] compared with direct protection against infection (58%; 95% CrI: 34 to 73%) and an estimated total efficacy of 89% (95% CrI: 74 to 96%). A mechanistic transmission model of bovine tuberculosis (bTB) spread within the Ethiopian dairy sector was developed and showed how the prospects for elimination may be enabled by routine BCG vaccination of cattle.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.adl3962

Reference60 articles.

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