Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring-Reference-Cited by-同舟云学术

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

Published:2014-02-07 Issue:6171 Volume:343 Page:675-679
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tyzio Roman¹²,Nardou Romain³,Ferrari Diana C.³,Tsintsadze Timur¹²³,Shahrokhi Amene³,Eftekhari Sanaz³,Khalilov Ilgam¹²,Tsintsadze Vera¹²,Brouchoud Corinne¹²,Chazal Genevieve¹²,Lemonnier Eric⁴,Lozovaya Natalia¹²,Burnashev Nail¹²,Ben-Ari Yehezkel¹²³

Affiliation:

1. Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France.

2. UMR 901, Aix-Marseille University, Marseille, France.

3. Neurochlore, Campus scientific de Luminy, 163 route de Luminy, Marseille 13273, Cedex 09, France.

4. Laboratoire de Neurosciences de Brest EA4685, Brest, France.

Abstract

The Switch That Doesn't In mammals, a class of neurons in the brain normally switches from excitatory to inhibitory functions at birth. Tyzio et al. (p. 675 ; see the Perspective by Zimmerman and Connors ) studied how these neurons function in rat and mouse models of autism. The results show that oxytocin normally accelerates the switch in function, but in these two animal models, the switch fails. The dysfunction could be replicated in normal animals using an oxytocin receptor antagonist.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors

2. Model of autism: increased ratio of excitation/inhibition in key neural systems

3. Common circuit defect of excitatory-inhibitory balance in mouse models of autism

4. Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications

5. GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations

Cited by 499 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour;Brain, Behavior, and Immunity;2024-10

2. Sortilin is associated with progranulin deficiency and autism‐like behaviors in valproic acid‐induced autism rats;CNS Neuroscience & Therapeutics;2024-09

3. Embryonic exposure to environmental factors drives transmitter switching in the neonatal mouse cortex causing autistic-like adult behavior;Proceedings of the National Academy of Sciences;2024-08-23

4. Reduced excitatory activity in the developing mPFC mediates a PVH-to-PVL transition and impaired social cognition in autism spectrum disorders;Translational Psychiatry;2024-08-06

5. Aerobic exercise improves cognitive flexibility and modulates regional volume changes in a rat model of autism;Behavioural Brain Research;2024-08