Mapping the human DC lineage through the integration of high-dimensional techniques-Reference-Cited by-同舟云学术

Mapping the human DC lineage through the integration of high-dimensional techniques

Published:2017-06-09 Issue:6342 Volume:356 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

See Peter¹^ORCID,Dutertre Charles-Antoine¹²,Chen Jinmiao¹^ORCID,Günther Patrick³^ORCID,McGovern Naomi¹^ORCID,Irac Sergio Erdal²^ORCID,Gunawan Merry⁴,Beyer Marc³⁵^ORCID,Händler Kristian³^ORCID,Duan Kaibo¹,Sumatoh Hermi Rizal Bin¹,Ruffin Nicolas⁶^ORCID,Jouve Mabel⁶^ORCID,Gea-Mallorquí Ester⁶^ORCID,Hennekam Raoul C. M.⁷,Lim Tony⁸,Yip Chan Chung⁹,Wen Ming²,Malleret Benoit¹¹⁰,Low Ivy¹^ORCID,Shadan Nurhidaya Binte¹^ORCID,Fen Charlene Foong Shu¹¹,Tay Alicia¹^ORCID,Lum Josephine¹^ORCID,Zolezzi Francesca¹,Larbi Anis¹,Poidinger Michael¹^ORCID,Chan Jerry K. Y.¹¹²¹³¹⁴,Chen Qingfeng¹⁵,Rénia Laurent¹^ORCID,Haniffa Muzlifah⁴^ORCID,Benaroch Philippe⁶,Schlitzer Andreas¹¹⁶,Schultze Joachim L.³⁵^ORCID,Newell Evan W.¹^ORCID,Ginhoux Florent¹^ORCID

Affiliation:

1. Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore.

2. Program in Emerging Infectious Disease, Duke-NUS Medical School, 8 College Road, 169857 Singapore.

3. Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, 32115 Bonn, Germany.

4. Institute of Cellular Medicine, Newcastle University, Newcastle, UK.

5. Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, 53175 Bonn, Germany.

6. Institut Curie, Paris Sciences et Lettres (PSL) Research University, INSERM U 932, F-75005, Paris, France.

7. Department of Pediatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.

8. Department of Anatomical Pathology, Singapore General Hospital, Singapore.

9. Department of Health Promotion Board (HPB) and Transplant Surgery, Singapore General Hospital, Singapore.

10. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

11. Singapore Health Services Flow Cytometry Core Platform, 20 College Road, The Academia, Discovery Tower Level 10, Singapore 169856, Singapore.

12. Department of Reproductive Medicine, Division of Obstetrics and Gynaecology, KK Women’s and Children’s Hospital, Singapore.

13. Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore.

14. Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

15. Humanized Mouse Unit, Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore.

16. Myeloid Cell Biology, Life and Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.

Abstract

Tracing development of the dendritic cell lineage Dendritic cells (DCs) are important components of the immune system that form from the bone marrow into two major cell lineages: plasmacytoid DCs and conventional DCs. See et al. applied single-cell RNA sequencing and cytometry by time-of-flight to characterize the developmental pathways of these cells. They identified blood DC precursors that shared surface markers with plasmacytoid DCs but that were functionally distinct. This unsuspected level of complexity in pre-DC populations reveals additional cell types and refines understanding of known cell types. Science , this issue p. eaag3009

Funder

Singapore Immunology Network

Agency for Science, Technology and Research

A*STAR Graduate Scholarship

Wellcome Trust

National Research Foundation Singapore

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference79 articles.

1. Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems