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Gene Expression Profiles in Normal and Cancer Cells

Published:1997-05-23 Issue:5316 Volume:276 Page:1268-1272
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Lin¹²³⁴,Zhou Wei¹²³⁴,Velculescu Victor E.¹²³⁴,Kern Scott E.¹²³⁴,Hruban Ralph H.¹²³⁴,Hamilton Stanley R.¹²³⁴,Vogelstein Bert¹²³⁴,Kinzler Kenneth W.¹²³⁴

Affiliation:

1. L. Zhang, W. Zhou, B. Vogelstein, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

2. V. E. Velculescu, Oncology Center and Program in Human Genetics and Molecular Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

3. S. E. Kern, R. H. Hruban, S. R. Hamilton, Department of Pathology and Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

4. K. W. Kinzler, Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Abstract

As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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