Reverse Transcriptase-Mediated Tropism Switching in Bordetella Bacteriophage-Reference-Cited by-同舟云学术

Reverse Transcriptase-Mediated Tropism Switching in Bordetella Bacteriophage

Published:2002-03-15 Issue:5562 Volume:295 Page:2091-2094
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Liu Minghsun¹,Deora Rajendar¹,Doulatov Sergei R.¹,Gingery Mari¹,Eiserling Frederick A.¹,Preston Andrew²,Maskell Duncan J.²,Simons Robert W.¹,Cotter Peggy A.³,Parkhill Julian⁴,Miller Jeff F.¹

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 OES, UK.

3. Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

4. The Sanger Centre, The Wellcome Trust Genome Campus, Hixton, Cambridge, UK.

Abstract

Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that generate diversity in a gene, designated mtd (major tropism determinant), which specifies tropism for receptor molecules on host Bordetella species. Tropism switching is the result of a template-dependent, reverse transcriptase–mediated process that introduces nucleotide substitutions at defined locations within mtd . This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

1. Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay.

2. P. A. Cotter J. F. Miller in Principles of Bacterial Pathogenesis E. A. Groisman Ed. (Academic Press San Diego 2001) pp. 620–674.

3. Ectopic expression of the flagellar regulon alters development of the bordetella-host interaction

4. A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvg‐regulated antigens

5. Identification and characterization of BipA, a Bordetella Bvg-intermediate phase protein

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