Lacteal junction zippering protects against diet-induced obesity-Reference-Cited by-同舟云学术

Lacteal junction zippering protects against diet-induced obesity

Published:2018-08-10 Issue:6402 Volume:361 Page:599-603
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Feng¹^ORCID,Zarkada Georgia¹^ORCID,Han Jinah¹,Li Jinyu¹^ORCID,Dubrac Alexandre¹^ORCID,Ola Roxana¹²^ORCID,Genet Gael¹,Boyé Kevin¹^ORCID,Michon Pauline¹³,Künzel Steffen E.¹^ORCID,Camporez Joao Paulo⁴,Singh Abhishek K.⁵^ORCID,Fong Guo-Hua⁶,Simons Michael¹^ORCID,Tso Patrick⁷,Fernández-Hernando Carlos⁵,Shulman Gerald I.⁴⁸^ORCID,Sessa William C.⁹^ORCID,Eichmann Anne¹³⁸^ORCID

Affiliation:

1. Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.

2. Department of Basic, Preventive and Clinical Science, University of Transylvania, 500019 Brasov, Romania.

3. INSERM U970, Paris Cardiovascular Research Center, 75015 Paris, France.

4. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

5. Departments of Comparative Medicine and Pathology, Vascular Biology and Therapeutics Program and Integrative Cell Signaling and Neurobiology of Metabolism Program, Yale University School of Medicine, New Haven, CT, USA.

6. Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, 06030-3501, USA.

7. Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237-0507, USA.

8. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.

9. Department of Pharmacology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.

Abstract

Zipping up obesity Chylomicrons are specialized particles that carry dietary fats from the intestine to the bloodstream for absorption into the body. Lacteals are lymphatic vessels that act as the highway for chylomicron transport, but it is unclear how passage occurs. Zhang et al. report that two endothelial cell receptors, neuropilin-1 (NRP1) and vascular endothelial growth factor receptor 1 (VEGFR1, also known as FLT1), are required to convert the entry spaces between lacteals from open junctions to closed, zipped structures (see the Perspective by McDonald). Mice that were fed a high-fat diet were subsequently rendered resistant to weight gain if NRP1 and FLT1 were inactivated. Science , this issue p. 599 ; see also p. 551

Funder

National Heart, Lung, and Blood Institute

National Eye Institute

American Heart Association

Agence Nationale de la Recherche

EMBO Long-Term Fellowships

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

1. Intestinal lymphatic vasculature: structure, mechanisms and functions