The Continuing Challenge of Understanding, Preventing, and Treating Neural Tube Defects-Reference-Cited by-同舟云学术

The Continuing Challenge of Understanding, Preventing, and Treating Neural Tube Defects

Published:2013-03 Issue:6123 Volume:339 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wallingford John B.¹,Niswander Lee A.²,Shaw Gary M.³,Finnell Richard H.⁴

Affiliation:

1. Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, TX 78712, USA.

2. Howard Hughes Medical Institute, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.

3. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Dell Pediatric Research Institute, Department of Nutritional Sciences and Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78723, USA

Abstract

Prevention or Repair Neural tube defects, such as spina bifida, remain remarkably common, despite widespread efforts to prevent them through supplementing maternal diets with folic acid. Surgery early in development has seen some success, but problems often remain. Wallingford et al. ( 10.1126/science.1222002 ) review normal and abnormal neural tube development and suggest that discovering the genetic risk factors for these serious birth defects could provide ways to prevent and treat neural tube defects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference102 articles.

1. Neural tube defects and folate: case far from closed

2. A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele

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4. Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America

5. How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals

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