Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy-Reference-Cited by-同舟云学术

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

Published:2021-04-30 Issue:6541 Volume:372 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Verweij Marieke C.¹^ORCID,Hansen Scott G.¹^ORCID,Iyer Ravi¹^ORCID,John Nessy¹^ORCID,Malouli Daniel¹^ORCID,Morrow David¹^ORCID,Scholz Isabel¹^ORCID,Womack Jennie¹^ORCID,Abdulhaqq Shaheed¹^ORCID,Gilbride Roxanne M.¹,Hughes Colette M.¹,Ventura Abigail B.¹^ORCID,Ford Julia C.¹^ORCID,Selseth Andrea N.¹^ORCID,Oswald Kelli²,Shoemaker Rebecca²,Berkemeier Brian²^ORCID,Bosche William J.²^ORCID,Hull Michael²,Shao Jason³^ORCID,Sacha Jonah B.¹,Axthelm Michael K.¹^ORCID,Edlefsen Paul T.³^ORCID,Lifson Jeffrey D.²^ORCID,Picker Louis J.¹^ORCID,Früh Klaus¹^ORCID

Affiliation:

1. Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

2. AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA.

3. Population Sciences and Computational Biology Programs, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

Viral peptide is key to T cell priming Simian immunodeficiency virus (SIV) vaccines containing a strain 68-1 rhesus cytomegalovirus (RhCMV) vector elicit strong CD8 + T cell responses that can control and clear SIV infections. The SIV peptides targeted by these T cells are presented on major histocompatibility complex (MHC) II and the nonclassical MHC-Ib molecule MHC-E rather than the more typical MHC-Ia. Verweij et al. show that the 68-1 RhCMV–encoded peptide VL9 drives intracellular transport of MHC-E and recognition of RhCMV-infected targets by MHC-E–restricted CD8 + T cells. Rhesus macaques vaccinated with a mutant 68-1 RhCMV lacking VL9 showed no priming of MHC-E–restricted CD8 + T cells and no protection against SIV. This work strongly suggests that future effective CMV-based HIV vaccines in humans will also require MHC-E–restricted CD8 + T cell priming. Science , this issue p. eabe9233

Funder

National Institutes of Health

NIH Office of the Director

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Bill and Melinda Gates Foundation supported Collaboration for AIDS Vaccine Discovery

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.

1. Diverse immune evasion strategies by human cytomegalovirus

2. Molecular characterization of HCMV-specific immune responses: Parallels between CD8+T cells, CD4+T cells, and NK cells

3. M. A. Jarvis S. G. Hansen J. A. Nelson L. J. Picker K. Früh “Vaccine vectors using the unique biology and immunology of cytomegalovirus ” in Cytomegaloviruses: From Molecular Pathogenesis to Intervention M. J. Reddehase Ed. (Caister Academic 2013) vol. 2 pp. 450–462.

4. T cell responses to cytomegalovirus

5. Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Deciphering the HLA-E immunopeptidome with mass spectrometry: an opportunity for universal mRNA vaccines and T-cell-directed immunotherapies;Frontiers in Immunology;2024-09-05

2. Regulation of the cell surface expression of classical and non-classical MHC proteins by the human cytomegalovirus UL40 and rhesus cytomegalovirus Rh67 proteins;Journal of Virology;2024-08-29

3. Mtbspecific HLA-E restricted T cells are induced duringMtbinfection but not after BCG administration in non-human primates and humans;2024-08-26

4. Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques;Frontiers in Immunology;2024-08-07

5. Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge;Nature Communications;2024-07-19