tRNAs Marked with CCACCA Are Targeted for Degradation-Reference-Cited by-同舟云学术

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tRNAs Marked with CCACCA Are Targeted for Degradation

Published:2011-11-11 Issue:6057 Volume:334 Page:817-821
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wilusz Jeremy E.¹,Whipple Joseph M.²,Phizicky Eric M.²,Sharp Phillip A.¹

Affiliation:

1. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester School of Medicine, Rochester, NY 14642, USA.

Abstract

Transfer RNAs with unstable acceptor stems can be tagged by CCA-adding enzymes and targeted for destruction by 3′-5′ exonucleases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. The -C-C-A End of tRNA and Its Role in Protein Biosynthesis

2. Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements

3. The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

4. tRNA biology charges to the front

5. 7 tRNA Nucleotidyltransferase

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