Affiliation:
1. Departments of Developmental Biology and Genetics, Howard Hughes Medical Institute, Beckman Center B300,
2. Department of Biochemistry, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305–5329, USA.
Abstract
The transcription factor Twist initiates
Drosophila
mesoderm development, resulting in the formation of heart, somatic muscle, and other cell types. Using a
Drosophila
embryo sorter, we isolated enough homozygous
twist
mutant embryos to perform DNA microarray experiments. Transcription profiles of
twist
loss-of-function embryos, embryos with ubiquitous
twist
expression, and wild-type embryos were compared at different developmental stages. The results implicate hundreds of genes, many with vertebrate homologs, in stage-specific processes in mesoderm development. One such gene,
gleeful
, related to the vertebrate
Gli
genes, is essential for somatic muscle development and sufficient to cause neural cells to express a muscle marker.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
231 articles.
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