Transduction of Human CD34 + Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors-Reference-Cited by-同舟云学术

Transduction of Human CD34 + Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors

Published:1999-01-29 Issue:5402 Volume:283 Page:682-686
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Miyoshi Hiroyuki¹,Smith Kent A.¹,Mosier Donald E.¹,Verma Inder M.¹,Torbett Bruce E.¹

Affiliation:

1. H. Miyoshi and I. M. Verma, Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. K. A. Smith, D. E. Mosier, B. E. Torbett, Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Efficient gene transfer into human hematopoietic stem cells (HSCs) is an important goal in the study of the hematopoietic system as well as for gene therapy of hematopoietic disorders. A lentiviral vector based on the human immunodeficiency virus (HIV) was able to transduce human CD34 + cells capable of stable, long-term reconstitution of nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. High-efficiency transduction occurred in the absence of cytokine stimulation and resulted in transgene expression in multiple lineages of human hematopoietic cells for up to 22 weeks after transplantation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference48 articles.

1. Metcalf D., Clin. Haematol. 8, 263 (1979);

2. McNiece I. K., et al., Blood 74, 609 (1989);

3. Sutherland H. J., Lansdorp P. M., Henkelman D. H., Eaves A. C., Eaves C. J., Proc. Natl. Acad. Sci. U.S.A. 87, 3584 (1990);

4. Hao Q. L., Thiemann F. T., Petersen D., Smogorzewska E. M., Crooks G. M., Blood 88, 3306 (1996).

5. Shultz L. D., et al., J. Immunol. 154, 180 (1995).

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