Acetaminophen: Potentially Toxic Metabolite Formed by Human Fetal and Adult Liver Microsomes and Isolated Fetal Liver Cells

Author:

Rollins D. E.1,von Bahr C.1,Glaumann H.2,Moldéus P.3,Rane A.1

Affiliation:

1. Department of Clinical Pharmacology, Huddinge University Hospital, Huddinge, Sweden

2. Departments of Clinical Pharmacology and Pathology, Karolinska Institute, Stockholm, Sweden

3. Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. BAHR, C.V., METABOLISM OF DESMETHYLIMIPRAMINE IN HUMAN FETAL AND ADULT LIVER-MICROSOMES, ACTA PHARMACOLOGICA ET TOXICOLOGICA 34: 58 (1974).

2. BUCKPITT, A.R., QUANTITATIVE-DETERMINATION OF GLUTATHIONE, CYSTEINE, AND N-ACETYL CYSTEINE CONJUGATES OF ACETAMINOPHEN BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY, ANALYTICAL BIOCHEMISTRY 83: 168 (1977).

3. DAVIS, M, PARACETAMOL OVERDOSE IN MAN - RELATIONSHIP BETWEEN PATTERN OF URINARY METABOLITES AND SEVERITY OF LIVER-DAMAGE, QUARTERLY JOURNAL OF MEDICINE 45: 181 (1976).

4. DRAYER, D.E., PHARMACOLOGICALLY ACTIVE DRUG METABOLITES - THERAPEUTIC AND TOXIC ACTIVITIES, PLASMA AND URINE DATA IN MAN, ACCUMULATION IN RENAL-FAILURE, CLINICAL PHARMACOKINETICS 1: 426 (1976).

5. DUTTON, G. J., BIOCHEMICAL JOURNAL 71: 141 (1959).

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