Evidence for Reduced Recombination on the Nondisjoined Chromosomes 21 in Down Syndrome

Author:

Warren Andrew C.1,Chakravarti Aravinda2,Wong Corinne1,Slaugenhaupt Susan A.2,Halloran Susan L.2,Watkins Paul C.1,Metaxotou Caterina3,Antonarakis Stylianos E.1

Affiliation:

1. Department of Pediatrics, Genetics Unit, and Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

2. Department of Biostatistics, Human Genetics Program, University of Pittsburgh, Pittsburgh, PA 15261. P. C. Watkins, Integrated Genetics Inc., Framingham, MA 01701.

3. First Department of Pediatrics, Cytogenetics Unit, Athens University Medical School, Athens, Greece.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. Alberman, E. D., Trisomy 21 Research Perspectives: 69 (1981).

2. ANTONARAKIS, S.E., ANALYSIS OF DNA HAPLOTYPES SUGGESTS A GENETIC PREDISPOSITION TO TRISOMY-21 ASSOCIATED WITH DNA-SEQUENCES ON CHROMOSOME-21, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 3360 (1985).

3. BAIKIE, A.G., 2 CASES OF LEUKAEMIA AND A CASE OF SEX-CHROMOSOME ABNORMALITY IN SAME SIBSHIP, LANCET 2: 1003 (1961).

4. BAKER, B.S., GENETIC-CONTROL OF MEIOSIS, ANNUAL REVIEW OF GENETICS 10: 53 (1976).

5. BOUE, J, CHROMOSOMAL ANALYSIS OF 2 CONSECUTIVE ABORTUSES IN EACH OF 43 WOMEN, HUMANGENETIK 19: 275 (1973).

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