Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva-Reference-Cited by-同舟云学术

Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva

Published:2005-07 Issue:5731 Volume:309 Page:131-133
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pain Arnab¹²³⁴⁵,Renauld Hubert¹²³⁴⁵,Berriman Matthew¹²³⁴⁵,Murphy Lee¹²³⁴⁵,Yeats Corin A.¹²³⁴⁵,Weir William¹²³⁴⁵,Kerhornou Arnaud¹²³⁴⁵,Aslett Martin¹²³⁴⁵,Bishop Richard¹²³⁴⁵,Bouchier Christiane¹²³⁴⁵,Cochet Madeleine¹²³⁴⁵,Coulson Richard M. R.¹²³⁴⁵,Cronin Ann¹²³⁴⁵,de Villiers Etienne P.¹²³⁴⁵,Fraser Audrey¹²³⁴⁵,Fosker Nigel¹²³⁴⁵,Gardner Malcolm¹²³⁴⁵,Goble Arlette¹²³⁴⁵,Griffiths-Jones Sam¹²³⁴⁵,Harris David E.¹²³⁴⁵,Katzer Frank¹²³⁴⁵,Larke Natasha¹²³⁴⁵,Lord Angela¹²³⁴⁵,Maser Pascal¹²³⁴⁵,McKellar Sue¹²³⁴⁵,Mooney Paul¹²³⁴⁵,Morton Fraser¹²³⁴⁵,Nene Vishvanath¹²³⁴⁵,O'Neil Susan¹²³⁴⁵,Price Claire¹²³⁴⁵,Quail Michael A.¹²³⁴⁵,Rabbinowitsch Ester¹²³⁴⁵,Rawlings Neil D.¹²³⁴⁵,Rutter Simon¹²³⁴⁵,Saunders David¹²³⁴⁵,Seeger Kathy¹²³⁴⁵,Shah Trushar¹²³⁴⁵,Squares Robert¹²³⁴⁵,Squares Steven¹²³⁴⁵,Tivey Adrian¹²³⁴⁵,Walker Alan R.¹²³⁴⁵,Woodward John¹²³⁴⁵,Dobbelaere Dirk A. E.¹²³⁴⁵,Langsley Gordon¹²³⁴⁵,Rajandream Marie-Adele¹²³⁴⁵,McKeever Declan¹²³⁴⁵,Shiels Brian¹²³⁴⁵,Tait Andrew¹²³⁴⁵,Barrell Bart¹²³⁴⁵,Hall Neil¹²³⁴⁵

Affiliation:

1. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

2. Division of Veterinary Infection and Immunity, Parasitology Group, Institute of Comparative Medicine, Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK.

3. The International Livestock Research Institute (ILRI), Post Office Box 30709, Nairobi, Kenya.

4. Plate-Forme Génomique–Pasteur Génopole, Ile de France Institut Pasteur, 25–28 rue du Docteur Roux, 75724 Paris, France.

5. Unité de Recherche Associée CNRS 2581, Département de Parasitologie, Bâtiment Elie Metchnikoff, Institut Pasteur, 25–28 rue du Docteur Roux, 75724 Paris Cedex 15, France.

Abstract

Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria -specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

1. Phylogeny and evolution of the piroplasms

2. Tissue Damage in Cattle Infected withTheileria annulataAccompanied by Metastasis of Cytokine-producing, Schizont-infected Mononuclear Phagocytes

3. The strategies of the Theileria parasite: a new twist in host–pathogen interactions

4. Materials and methods are available as supporting material on Science Online.

5. Genome Sequence of Theileria parva , a Bovine Pathogen That Transforms Lymphocytes

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